Sileo (dexmedetomidine oromucosal gel)

The simple, effective
and safe solution to the signs of
noise aversion, such as pacing,
lip licking, shaking,
and panting.

Sileo product box and syringe

SILEO is a medication prescribed by your veterinarian to help calm your dog when frightened by loud noises (noise aversion). Common noise aversion triggers include fireworks, thunder, construction work, traffic or street noise, celebrations, vacuum cleaners and smoke detectors.

SILEO is different from other treatments and medications:

  • The first FDA-approved treatment for noise aversion in dogs—works the way you need it to.
  • Clinically proven to be safe and effective without other treatments or training.
  • A practical, fast-acting, easy-to-administer at-home treatment for noise aversion.
  • Use, as needed, for each noise event.
  • Calms without sedating, which allows your dog to interact normally with the family.

Does your dog suffer from noise anxiety, also called noise aversion?

Look for these common behaviors.

Use the Checklist

Important Safety Information: Do not use SILEO in dogs with severe cardiovascular disease, respiratory, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue or in dogs hypersensitive to dexmedetomidine or to any of the excipients. SILEO should not be administered in the presence of preexisting hypotension, hypoxia, or bradycardia. Do not use in dogs sedated from previous dosing. SILEO has not been evaluated in dogs younger than 16 weeks of age or in dogs with dental or gingival disease that could have an effect on the absorption of SILEO. SILEO has not been evaluated for use in breeding, pregnant, or lactating dogs or for aversion behaviors to thunderstorms. Transient pale mucous membranes at the site of application may occur with SILEO use. Other uncommon adverse reactions included emesis, drowsiness or sedation. Handlers should avoid direct exposure of SILEO to their skin, eyes or mouth. Failure to lock the ring-stop on the syringe before dosing SILEO could potentially lead to an accidental overdose. Always review INSTRUCTIONS FOR USE before dispensing and dosing. See full Prescribing Information.

The product information provided in this site is intended only for residents of the United States. The products discussed herein may not have marketing authorization or may have different product labeling in different countries. The animal health information contained herein is provided for educational purposes only and is not intended to replace discussions with an animal healthcare professional. All decisions regarding the care of a veterinary patient must be made with an animal healthcare professional, considering the unique characteristics of the patient.

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SILEO® is trademark owned by Orion Corporation Orion Pharma Animal Health. It is manufactured by Orion Corporation and distributed by Zoetis under license from Orion Corporation Orion Pharma Animal Health.
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