Sileo (dexmedetomidine oromucosal gel)

Do fireworks, thunder, and other loud noises make your dog anxious and fearful?

See if your dog suffers from noise aversion

Use this checklist to identify triggers and behaviors. Then click "See Report" below. This report can be printed or emailed to you to share with your veterinarian.

Noise Triggers

Which trigger(s) cause your dog's behavioral changes?

  • Fireworks
  • Thunder
  • Celebrations
  • Construction work
  • Traffic or street noise
  • Other


Which behaviors happen during noise events?

  • Pacing or restlessness
  • Lip licking
  • Trembling or shaking
  • Panting
  • Excessive vigilance or hypervigilance
  • Cowering
  • Hiding
  • Brow furrowed or ears back
  • Freezing or immobility
  • Owner seeking behavior or abnormal clinginess
  • Refuses to eat
  • Yawning
  • Vocalizing (whining or barking at the sounds)

More Information

How often does your dog react to noise triggers?

Describe the intensity of your dog's reaction to noise triggers:

How long does it take for your dog to recover from a reaction to noise triggers?

See Report »

Important Safety Information: Do not use SILEO in dogs with severe cardiovascular disease, respiratory, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue or in dogs hypersensitive to dexmedetomidine or to any of the excipients. SILEO should not be administered in the presence of preexisting hypotension, hypoxia, or bradycardia. Do not use in dogs sedated from previous dosing. SILEO has not been evaluated in dogs younger than 16 weeks of age or in dogs with dental or gingival disease that could have an effect on the absorption of SILEO. SILEO has not been evaluated for use in breeding, pregnant, or lactating dogs or for aversion behaviors to thunderstorms. Transient pale mucous membranes at the site of application may occur with SILEO use. Other uncommon adverse reactions included emesis, drowsiness or sedation. Handlers should avoid direct exposure of SILEO to their skin, eyes or mouth. Failure to lock the ring-stop on the syringe before dosing SILEO could potentially lead to an accidental overdose. Always review INSTRUCTIONS FOR USE before dispensing and dosing. See full Prescribing Information.Prescribing Information.


  1. Based on online survey conducted by Harris Poll on behalf of Zoetis in November 2013 among 784 dog owners.
  2. Sherman BL, Mills DS. Canine anxieties and phobias: an update on separation anxiety and noise aversions. Vet Clin Nor Amer: Small Anim Pract. 2008;38(5):1081-1106.
  3. Shull-Selcer EA, Stagg W. Advances in the understanding and treatment of noise phobias. Vet Clin Nor Amer: Small Anim Pract. 1991;21(2):353-367.

The product information provided in this site is intended only for residents of the United States. The products discussed herein may not have marketing authorization or may have different product labeling in different countries. The animal health information contained herein is provided for educational purposes only and is not intended to replace discussions with an animal healthcare professional. All decisions regarding the care of a veterinary patient must be made with an animal healthcare professional, considering the unique characteristics of the patient.

Terms of Use

SILEO® is trademark owned by Orion Corporation Orion Pharma Animal Health. It is manufactured by Orion Corporation and distributed by Zoetis under license from Orion Corporation Orion Pharma Animal Health.
©2019 Zoetis Services LLC. All rights reserved. SIL-00112R2