Sileo (dexmedetomidine oromucosal gel)

Treatment starts with an effective medication such as SILEO.

In addition to SILEO, you can take the following simple steps to modify your dog’s home environment:

  • Restrict or minimize exposure to noises that cause your dog to be afraid.
  • Play music to mask noises that scare your dog. Classical music has been shown to be calming for some dogs.4
  • During fireworks, close the curtains and keep the room brightly lit to limit visual stimulation.
  • Encourage your dog to go to a soundproof area such as a basement, closet or bathroom. These areas can be safe havens for your dog; once the noise begins, your dog can retreat to this area and feel relatively safe. Talk with your veterinarian on how to set up a safe haven for your dog.
  • Be present: your presence itself is comforting to your dog.
  • Act normal: for example, play with your dog, read a book or watch TV, regardless of the noise.

Actions to avoid:

  • Never punish your dog for having accidents indoors or damaging property during noise events. It makes your dog even more afraid of the noise. And remember, dogs are acting out of fear, not misbehaving.
  • Avoid telling your dog that "It’s OK" or petting your dog during noise events. For example:
    • When you say, "It’s OK," your dog hears that it is "OK" to pace, pant or bark during the noise event.
    • Petting your dog sends a similar message as saying "It’s OK".

These recommendations will help you and your dog cope better during the noise event. But you should still seek the help of a veterinarian. It’s important to talk with your veterinarian about your dog’s noise aversion behaviors.

Does your dog suffer from noise aversion?

Look for these common behaviors.

Use the Checklist

Important Safety Information: Do not use SILEO in dogs with severe cardiovascular disease, respiratory, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue or in dogs hypersensitive to dexmedetomidine or to any of the excipients. SILEO should not be administered in the presence of preexisting hypotension, hypoxia, or bradycardia. Do not use in dogs sedated from previous dosing. SILEO has not been evaluated in dogs younger than 16 weeks of age or in dogs with dental or gingival disease that could have an effect on the absorption of SILEO. SILEO has not been evaluated for use in breeding, pregnant, or lactating dogs or for aversion behaviors to thunderstorms. Transient pale mucous membranes at the site of application may occur with SILEO use. Other uncommon adverse reactions included emesis, drowsiness or sedation. Handlers should avoid direct exposure of SILEO to their skin, eyes or mouth. Failure to lock the ring-stop on the syringe before dosing SILEO could potentially lead to an accidental overdose. Always review INSTRUCTIONS FOR USE before dispensing and dosing. See full Prescribing Information.


  1. Wells DL, Graham L, Hepper PG. The influence of auditory stimulation on the behaviour of dogs housed in a rescue shelter. Anim Welf. 2002;11(4):385-393.

The product information provided in this site is intended only for residents of the United States. The products discussed herein may not have marketing authorization or may have different product labeling in different countries. The animal health information contained herein is provided for educational purposes only and is not intended to replace discussions with an animal healthcare professional. All decisions regarding the care of a veterinary patient must be made with an animal healthcare professional, considering the unique characteristics of the patient.

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